Affiliation:
1. Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States
Abstract
Aging is the most prominent nonmodifiable risk factor for various human diseases including Idiopathic pulmonary fibrosis. Aging progressively alters extracellular matrix components and is associated with the accumulation of senescent cells that promote age-related tissue dysfunction. In this review, we will discuss the pathological impact of aging and senescence on lung fibrosis via senescence-associated secretary phenotype factors and potential therapeutic approaches to limit the progression of lung fibrosis.
Funder
HHS | NIH | NHLBI | NHLBI Division of Intramural Research
HHS | NIH | National Heart, Lung, and Blood Institute
HHS | NIH | National Institute on Aging
OSU | College of Medicine Office of Research, Ohio State University
Publisher
American Physiological Society
Cited by
4 articles.
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