Microscopic computed tomography with AI-CNN-powered image analysis: the path to phenotype bleomycin-induced lung injury-Reference-Cited by-同舟云学术

Microscopic computed tomography with AI-CNN-powered image analysis: the path to phenotype bleomycin-induced lung injury

Published:2024-06-01 Issue:6 Volume:326 Page:C1637-C1647
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Henneke Ingrid¹²,Pilz Christina²,Wilhelm Jochen²³^ORCID,Alexopoulos Ioannis²⁴^ORCID,Ezaddoustdar Aysan²⁵,Mukhametshina Regina²⁶,Weissmann Norbert²^ORCID,Ghofrani Hossein Ardeschir²^ORCID,Grimminger Friedrich²⁷,Seeger Werner²⁷⁸^ORCID,Schermuly Ralph T.²,Wygrecka Malgorzata²⁵⁹^ORCID,Kojonazarov Baktybek²⁶^ORCID

Affiliation:

1. Experimental Lung Disease Models Platform, Institute for Lung Health (ILH), Justus Liebig University (JLU), Giessen, Germany

2. Department of Internal Medicine, Member of the German Center for Lung Research (DZL), Member of the Excellence Cluster Cardio-Pulmonary Institute (CPI), Universities of Giessen and Murburg Lung Center (UGMLC), Justus Liebig University (JLU), Giessen, Germany

3. Genomics and Bioinformatics Platform, Institute for Lung Health (ILH), Justus Liebig University (JLU), Giessen, Germany

4. Multyscale Imaging Platform, Institute for Lung Health (ILH), Justus Liebig University (JLU), Giessen, Germany

5. Center for Infection and Genomics of the Lung (CIGL), Faculty of Medicine, Justus Liebig University (JLU), Giessen, Germany

6. Small Animal Imaging Platform, Institute for Lung Health (ILH), Justus Liebig University (JLU), Giessen, Germany

7. Institute for Lung Health (ILH), Justus Liebig University (JLU), Giessen, Germany

8. Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany

9. CSL Behring Innovation GmbH, Marburg, Germany

Abstract

Microscopic computed tomography (µCT) imaging combined with an artificial intelligence (AI)-convolutional neural network (CNN)-powered lung segmentation is a rapid and powerful tool for noninvasive phenotyping of bleomycin mice over the course of the disease. This, in turn, allows earlier and more reliable identification of therapeutic effects of new drug candidates, ultimately leading to the reduction of unnecessary procedures in animals in pharmacological research.

Funder

Deutsche Forschungsgemeinschaft

Deutsches Zentrum für Lungenforschung

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00708.2023

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