Notch1 Induces Defective Epithelial Surfactant Processing and Pulmonary Fibrosis

Author:

Wasnick Roxana1ORCID,Korfei Martina1,Piskulak Katarzyna1,Henneke Ingrid123,Wilhelm Jochen123,Mahavadi Poornima12,Dartsch Ruth Charlotte1,von der Beck Daniel1ORCID,Koch Miriam14,Shalashova Irina1,Weiss Astrid1,Klymenko Oleksiy1,Askevold Ingolf5,Fink Ludger6,Witt Heiko7,Hackstein Holger8,El Agha Elie123,Bellusci Saverio123,Klepetko Walter9,Königshoff Melanie1011ORCID,Eickelberg Oliver11ORCID,Schermuly Ralph Theo123,Braun Thomas12312,Seeger Werner12312,Ruppert Clemens1213,Guenther Andreas123413ORCID

Affiliation:

1. University of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), 35392 Giessen, Germany;

2. Excellence Cluster Cardiopulmonary Institute (CPI), 35392 Giessen, Germany;

3. Institute for Lung Health (ILH), 35392 Giessen, Germany;

4. Lung Clinic, Evangelisches Krankenhaus Mittelhessen, 35398 Giessen, Germany;

5. Department of Surgery, Justus-Liebig-University Giessen, 35392 Giessen, Germany;

6. Institut für Pathologie, Überregionale Gemeinschaftspraxis für Pathologie und Zytologie, 35578 Wetzlar, Germany;

7. Pediatric Nutritional Medicine, Else-Kröner-Fresenius-Fresenius-Ceter for Nutritional Sciences, Technical University Munich, 85354 Freising, Germany;

8. Department of Clinical Immunology and Transfusion Medicine, Justus-Liebig University Giessen, 35392 Giessen, Germany;

9. Department of Thoracic Surgery, Vienna General Hospital, 1090 Vienna, Austria;

10. Comprehensive Pneumology Center, Research Unit Lung Repair and Regeneration, Helmholtz Center Munich, Ludwig Maximilians University Munich, 81377 Munich, Germany;

11. Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261;

12. Max-Planck-Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany; and

13. European IPF Registry/Biobank, 35392 Giessen, Germany

Funder

German Center for Lung Research

European Commission

German Research Council

Lung Fibrosis Foundation Waldhof-Elgershausen

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

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