Cancer survivors post-chemotherapy exhibit unimpaired short-latency stretch reflexes in the proximal upper extremity-Reference-Cited by-同舟云学术

Cancer survivors post-chemotherapy exhibit unimpaired short-latency stretch reflexes in the proximal upper extremity

Published:2023-10-01 Issue:4 Volume:130 Page:895-909
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Wang Allison B.¹²³^ORCID,Housley Stephen N.⁴,Ludvig Daniel¹³^ORCID,Franz Colin K.³⁵⁶^ORCID,Flores Ann Marie²⁷⁸^ORCID,Cope Timothy C.⁴⁹¹⁰^ORCID,Perreault Eric J.¹³⁵^ORCID

Affiliation:

1. Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, United States

2. Department of Physical Therapy and Human Movement Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States

3. Shirley Ryan AbilityLab, Chicago, Illinois, United States

4. School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia, United States

5. Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States

6. The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States

7. Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States

8. Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States

9. W.H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Georgia Institute of Technology, Atlanta, Georgia, United States

10. Integrated Cancer Research Center, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, United States

Abstract

Our results showed that cancer survivors after oxaliplatin (OX) treatment exhibited stretch reflexes that were comparable with age-matched healthy individuals in the proximal upper limb. The lack of OX effect might be linked to differences between the clinical and preclinical testing paradigms. These findings refine our expectations derived from the preclinical study and guide future assessments of OX effects that may have been insensitive to our measurement techniques.

Funder

Northside Hospital Foundation, Inc.

HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of Biomedical Imaging and Bioengineering

HHS | NIH | National Institute of Neurological Disorders and Stroke

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00299.2022