Exposure to binge ethanol and fatty acid ethyl esters exacerbates chronic ethanol-induced pancreatic injury in hepatic alcohol dehydrogenase-deficient deer mice-Reference-Cited by-同舟云学术

Exposure to binge ethanol and fatty acid ethyl esters exacerbates chronic ethanol-induced pancreatic injury in hepatic alcohol dehydrogenase-deficient deer mice

Published:2022-03-01 Issue:3 Volume:322 Page:G327-G345
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Srinivasan Mukund P.¹^ORCID,Bhopale Kamlesh K.¹,Caracheo Anna A.¹,Kaphalia Lata²,Gong Bin¹,Popov Vsevolod L.¹,Boor Paul J.¹,Shakeel Ansari G. A.¹,Kaphalia Bhupendra S.¹^ORCID

Affiliation:

1. Department of Pathology, The University of Texas Medical Branch, Galveston, Texas

2. Department of Internal Medicine, The University of Texas Medical Branch, Galveston, Texas

Abstract

We established a chronic EtOH feeding model of hepatic alcohol dehydrogenase-deficient (ADH−) deer mice, which mimics several fibroinflammatory features of human alcoholic chronic pancreatitis (ACP). The fibroinflammatory and morphological features exacerbated by chronic plus binge EtOH and FAEEs exposure provide a strong case for metabolic basis of ACP. Most importantly, several pathological and molecular targets identified in this study provide a much broader understanding of the mechanism and avenues to develop therapeutics for ACP.

Funder

HHS | NIH | National Institute on Alcohol Abuse and Alcoholism

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00263.2021

Reference65 articles.

1. Alcohol and Smoking as Risk Factors in an Epidemiology Study of Patients With Chronic Pancreatitis

2. Investigating the Pathobiology of Alcoholic Pancreatitis

3. Alcoholic pancreatitis: New insights into the pathogenesis and treatment

4. Recent Advances in Understanding the Complexity of Alcohol-Induced Pancreatic Dysfunction and Pancreatitis Development

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The role of gut microbiome and its metabolites in pancreatitis;mSystems;2024-08-30

2. Protective Effects and Mechanism of Heracleum moellendorffii Hance on Alcohol-Induced Cognitive Decline in Mice;International Journal of Molecular Sciences;2024-08-05

3. Differences in Plasma Fatty Acid Composition Related to Chronic Pancreatitis;Pancreas;2024-03-13

4. Dysregulated pancreatic lipid phenotype, inflammation and cellular injury in a chronic ethanol feeding model of hepatic alcohol dehydrogenase-deficient deer mice;Life Sciences;2023-06

5. Fatty Acid Ethyl Ethers: New Modulators of Acute Ethanol-Mediated Hepatotoxicity?;Cellular and Molecular Gastroenterology and Hepatology;2023