Stimulus intensity-dependent recruitment of NaV1 subunits in action potential initiation in nerve terminals of vagal C-fibers innervating the esophagus-Reference-Cited by-同舟云学术

Stimulus intensity-dependent recruitment of NaV1 subunits in action potential initiation in nerve terminals of vagal C-fibers innervating the esophagus

Published:2020-10-01 Issue:4 Volume:319 Page:G443-G453
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Ru Fei¹,Pavelkova Nikoleta²,Krajewski Jeffrey L.³,McDermott Jeff S.³,Undem Bradley J.¹,Kollarik Marian²^ORCID

Affiliation:

1. Johns Hopkins University School of Medicine, Baltimore, Maryland

2. University of South Florida, Morsani College of Medicine, Tampa, Florida

3. Lilly Research Laboratories, Indianapolis, Indiana

Abstract

We report that pharmacologically distinguishable voltage-gated sodium channels (NaV1) mediate action potential initiation at low (innocuous) versus high (noxious) intensity of esophageal distention in nerve terminals of vagal nodose C-fibers. Action potential initiation at low intensity is entirely dependent on NaV1.7; however, additional tetrodotoxin (TTX)-sensitive NaV1s are recruited at higher intensity of distention. This is the first demonstration that NaV1s underlying action potential initiation in visceral C-fibers depend on the intensity of the stimulus.

Funder

HHS | National Institutes of Health

Eli Lilly and Company

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00122.2019

Reference34 articles.

1. Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release

2. Experimental ulcers alter voltage-sensitive sodium currents in rat gastric sensory neurons