Action potential conduction in the mouse and rat vagus nerve is dependent on multiple voltage-gated sodium channels (Na<sub>V</sub>1s)-Reference-Cited by-同舟云学术

Action potential conduction in the mouse and rat vagus nerve is dependent on multiple voltage-gated sodium channels (Na_V1s)

Published:2023-09-01 Issue:3 Volume:130 Page:684-693
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Nair Sanjay S.¹^ORCID,Pavelkova Nikoleta¹,Murphy Claire M.¹^ORCID,Kollarik Marian¹^ORCID,Taylor-Clark Thomas E.¹^ORCID

Affiliation:

1. Department of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States

Abstract

Distinct NaV1 channels are involved in action potential (AP) initiation and conduction from afferent terminals within specific organs. Here, we have identified the NaV1 necessary for AP conduction in the entire murine and rat vagus nerve. We show TTX-sensitive channels are essential for all AP conduction, predominantly NaV1.7 with NaV1.2 and NaV1.6 playing lesser roles depending on the species and fiber type. In addition, we show that NaV1.8 is also essential for most axonal AP conduction.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00041.2023

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