Affiliation:
1. Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139
Abstract
Chronic gastrointestinal and liver infections account for a significant percentage of human cancer deaths. Rodent models help elucidate how infection can lead to malignancy. Helicobacter pylori, the leading cause of human gastric tumors, produces similar disease in Mongolian gerbils. H. pylori, H. felis, and H. hepaticus induce stomach, lower bowel, or liver tumors in susceptible wild-type and genetically engineered mice. Immune dysregulated mice recapitulate features of inflammatory bowel disease including colon carcinoma. Hepatitis B and C virus transgenic mice provide insights into viral hepatitis and hepatocellular carcinoma. Rodent models enhance our understanding of infectious cancer pathogenesis and suggest novel targets for intervention.
Publisher
American Physiological Society
Subject
Physiology (medical),Gastroenterology,Hepatology,Physiology
Reference25 articles.
1. Engle SJ, Ormsby I, Pawlowski S, Boivin GP, Croft J, Balish E, and Doetschman T.Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice.Cancer Res62: 6362-6366, 2002.
2. CD4+ CD25+ Regulatory T Lymphocytes Inhibit Microbially Induced Colon Cancer in Rag2-Deficient Mice
3. Erdman SE, Rao VP, Poutahidis T, Ihrig MM, Ge Z, Feng Y, Tomczak M, Rogers AB, Horwitz BH, and Fox JG.CD4(+)CD25(+) regulatory lymphocytes require interleukin 10 to interrupt colon carcinogenesis in mice.Cancer Res63: 6042-6050, 2003.
4. Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces helicobacter-induced gastric atrophy
5. Hepatic Helicobacter species identified in bile and gallbladder tissue from chileans with chronic cholecystitis
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