One Shoot, Two Birds: Alleviating Inflammation Caused by Ischemia/Reperfusion Injury to Reduce the Recurrence of Hepatocellular Carcinoma

Author:

Chen Hao,Lu Di,Yang Xinyu,Hu Zhihang,He Chiyu,Li Huigang,Lin Zuyuan,Yang Modan,Xu Xiao

Abstract

Inflammation is crucial to tumorigenesis and the development of metastasis. Hepatic ischemia/reperfusion injury (IRI) is an unresolved problem in liver resection and transplantation which often establishes and remodels the inflammatory microenvironment in liver. More and more experimental and clinical evidence unmasks the role of hepatic IRI and associated inflammation in promoting the recurrence of hepatocellular carcinoma (HCC). Meanwhile, approaches aimed at alleviating hepatic IRI, such as machine perfusion, regulating the gut-liver axis, and targeting key inflammatory components, have been proved to prevent HCC recurrence. This review article highlights the underlying mechanisms and promising therapeutic strategies to reduce tumor recurrence through alleviating inflammation induced by hepatic IRI.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Primary Research and Development Plan of Zhejiang Province

Publisher

Frontiers Media SA

Subject

Immunology,Immunology and Allergy

Reference105 articles.

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