Lipopolysaccharides transport during fat absorption in rodent small intestine-Reference-Cited by-同舟云学术

Lipopolysaccharides transport during fat absorption in rodent small intestine

Published:2020-06-01 Issue:6 Volume:318 Page:G1070-G1087
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Akiba Yasutada¹²³^ORCID,Maruta Koji²,Takajo Takeshi²,Narimatsu Kazuyuki²,Said Hyder²,Kato Ikuo⁴,Kuwahara Atsukazu⁵,Kaunitz Jonathan D.¹²⁶³^ORCID

Affiliation:

1. Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, California

2. Department of Medicine, University of California, School of Medicine, Los Angeles, California

3. Brentwood Biomedical Research Institute, Los Angeles, California

4. Department of Medical Biochemistry, Kobe Pharmaceutical University, Kobe, Japan

5. Research Unit for Epithelial Physiology, Research Organization of Science and Technology, Ritsumeikan University, Kusatsu, Japan

6. Department of Surgery, University of California, School of Medicine, Los Angeles, California

Abstract

We report direct in vivo confirmation of transcellular lipopolysaccharides (LPS) uptake from the intestine into the portal vein (PV) involving CD36 and lipid rafts, with minor uptake via the canonical chylomicron pathway. The gut hormone glucagon-like peptide-2 (GLP-2) inhibited uptake into the PV. These data suggest that the bulk of LPS absorption is via the PV to the liver, helping clarify the mechanism of LPS transport into the PV as part of the “gut-liver” axis. These data do not support the paracellular transport of LPS, which has been implicated in the pathogenesis of the “leaky gut” syndrome.

Funder

U.S. Department of Veterans Affairs

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Shire

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00079.2020

Reference91 articles.

1. Short-chain fatty acid sensing in rat duodenum