Defense mechanisms to increasing back pressure for hepatic oxygen transport and venous return in porcine fecal peritonitis

Author:

Liu Shengchen12,do Amaral Campos Pedro Paulo Zanella3,Casoni Daniela4,Berger David1,Kohler Andreas5ORCID,Bloch Andreas1,Bervini David6,Setzer Florian1,Cameron David R.1,Z'Graggen Werner6ORCID,Hana Anisa1,Langer Rupert7,Corrêa Thiago D.3,Beldi Guido5,Takala Jukka1,Jakob Stephan M.1

Affiliation:

1. Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

2. Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland

3. Department of Intensive Care Unit, Hospital Israelita Albert Einstein, Sao Paulo, Brazil

4. Experimental Surgery Facility, Department for BioMedical Research, University of Bern, Bern, Switzerland

5. Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

6. Department of Neurosurgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

7. Institue of Pathology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

Abstract

Sepsis impairs intrinsic mechanisms to attenuate effects of increasing back pressure on hepatic oxygen transport.

Funder

Foundation for research in anesthesiology and intensive care medicine

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

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