Hepatic blood flow regulation but not oxygen extraction capability is impaired in prolonged experimental abdominal sepsis-Reference-Cited by-同舟云学术

Hepatic blood flow regulation but not oxygen extraction capability is impaired in prolonged experimental abdominal sepsis

Published:2022-10-01 Issue:4 Volume:323 Page:G348-G361
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Liu Shengchen¹²³,Kohler Andreas⁴^ORCID,Langer Rupert⁵,Jakob Manuel O.⁴,Salm Lilian⁴,Blank Annika⁶,Beldi Guido⁴,Jakob Stephan M.¹^ORCID

Affiliation:

1. Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

2. Department of Cardio-thoracic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, People’s Republic of China

3. Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland

4. Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

5. Institute of Pathology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

6. Institute of Pathology, Triemlispital Zürich, Zürich, Switzerland

Abstract

The capacity to acutely increase hepatic O2 extraction with portal flow reduction is maintained in sepsis with accompanying liver injury, but hepatic blood flow regulation is impaired.

Funder

Inselspital, University Hospital of Bern

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00109.2022

Reference69 articles.

1. Incidence and prognosis of early hepatic dysfunction in critically ill patients—A prospective multicenter study

2. New Translational Research Provides Insights into Liver Dysfunction in Sepsis

3. Hepatic Parenchymal Oxygen Tension Following Injury and Sepsis

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Comparative pharmacokinetic study of Anisodamine Hydrobromide tablets and injection in septic acute lung injury rats;Bioanalysis;2024-08-08

2. Autonomic and circulatory alterations persist despite adequate resuscitation in a 5-day sepsis swine experiment;Scientific Reports;2022-11-11