GLUT5 is a determinant of dietary fructose-mediated exacerbation of experimental colitis-Reference-Cited by-同舟云学术

GLUT5 is a determinant of dietary fructose-mediated exacerbation of experimental colitis

Published:2021-08-01 Issue:2 Volume:321 Page:G232-G242
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Basu Srijani¹^ORCID,Liu Catherine¹,Zhou Xi Kathy²,Nishiguchi Ryohei¹,Ha Taehoon²,Chen Justin¹,Johncilla Melanie³,Yantiss Rhonda K.³,Montrose David C.⁴⁵^ORCID,Dannenberg Andrew J.¹

Affiliation:

1. Department of Medicine, Weill Cornell Medicine, New York, New York

2. Department of Population Health Sciences, Weill Cornell Medicine, New York, New York

3. Department of Pathology & Laboratory Medicine, Weill Cornell Medicine, New York, New York

4. Department of Pathology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York

5. Stony Brook Cancer Center, Stony Brook, New York

Abstract

This study provides the first evidence that reduced levels of GLUT5, the fructose transporter, worsen experimental colitis upon fructose feeding, an effect mediated by changes in the gut microbiota. Moreover, GLUT5 expression is reduced in Crohn’s ileitis. Overall, these findings demonstrate the importance of interactions between dietary fructose and host GLUT5 as determinants of both the composition of colonic microbiota and severity of experimental colitis.

Funder

Career Development Award from Crohn's and Colitis foundation

New York Crohns Foundation

Jill Roberts IBD research fund in honor of Ellen J Scherl

Tokyo Clinical Surgical Association

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00059.2021

Reference36 articles.