Effect of chronic alcohol exposure on gut vitamin B7 uptake: involvement of epigenetic mechanisms and effect of alcohol metabolites-Reference-Cited by-同舟云学术

Effect of chronic alcohol exposure on gut vitamin B7 uptake: involvement of epigenetic mechanisms and effect of alcohol metabolites

Published:2021-08-01 Issue:2 Volume:321 Page:G123-G133
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Ramamoorthy Kalidas¹,Sabui Subrata¹²,Srinivasan Padmanabhan¹²,Al-Juburi Saleh¹,Pham Quang¹,Chu Brian D.¹²,Simoes Rita D.³,Fleckenstein James M.³⁴,Said Hamid M.¹⁵²

Affiliation:

1. Department of Physiology/Biophysics, University of California, Irvine, California

2. Veterans Affairs Medical Center, Long Beach, California

3. Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri

4. Veterans Affairs Medical Center, St. Louis Missouri

5. Department of Medicine, University of California, Irvine, California

Abstract

Using complementary models, including human differentiated enteroid and colonoid monolayers, this study shows the involvement of molecular and epigenetic mechanisms in mediating the inhibitory effect of chronic alcohol exposure on biotin uptake along the intestinal tract. The study also shows that alcohol metabolites (generated by gut microbiota and host tissues) cause inhibition in gut biotin uptake.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Institute on Alcohol Abuse and Alcoholism

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00144.2021

Reference54 articles.