Stabilization of <i>Cx43</i> mRNA via RNA-binding protein HuR regulated by polyamines enhances intestinal epithelial barrier function-Reference-Cited by-同舟云学术

Stabilization of Cx43 mRNA via RNA-binding protein HuR regulated by polyamines enhances intestinal epithelial barrier function

Published:2023-12-01 Issue:6 Volume:325 Page:G518-G527
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Wang Shelley R.¹,Mallard Caroline G.¹,Cairns Cassandra A.¹^ORCID,Chung Hee Kyoung¹,Yoo Dongyoon¹,Jaladanki Suraj K.¹,Xiao Lan¹,Wang Jian-Ying¹²³^ORCID

Affiliation:

1. Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, United States

2. Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, United States

3. Baltimore Veterans Affairs Medical Center, Baltimore, Maryland, United States

Abstract

The current study shows that polyamines stabilize the Cx43 mRNA via HuR, thus enhancing the function of the Cx43-mediated gap junction. These findings suggest that induced Cx43 by HuR plays a critical role in the process by which polyamines regulate intestinal epithelial barrier.

Funder

Foundation for the National Institutes of Health

VA | Iowa City Veterans Affairs Medical Center

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00143.2023

Reference60 articles.

1. Gap junctions: structure and function (Review)

2. Tight junction proteins in gastrointestinal and liver disease

3. Regulation of Gut Barrier Function by RNA-Binding Proteins and Noncoding RNAs

4. Polyamines in Gut Epithelial Renewal and Barrier Function

5. RNA-binding proteins and microRNAs in gastrointestinal epithelial homeostasis and diseases

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