Interaction between microRNA-195 and HuR regulates Paneth cell function in the intestinal epithelium by altering SOX9 translation-Reference-Cited by-同舟云学术

Interaction between microRNA-195 and HuR regulates Paneth cell function in the intestinal epithelium by altering SOX9 translation

Published:2024-09-01 Issue:3 Volume:327 Page:C817-C829
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Kwon Min S.¹,Chung Hee K.¹,Xiao Lan¹²,Yu Ting-Xi¹,Sharma Shweta¹,Cairns Cassandra M.¹^ORCID,Chen Ting¹,Chae Songah¹,Turner Douglas J.¹²^ORCID,Wang Jian-Ying¹²³^ORCID

Affiliation:

1. Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, United States

2. Baltimore Veterans Affairs Medical Center, Baltimore, Maryland, United States

3. Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, United States

Abstract

Our results indicate that intestinal epithelial tissue-specific transgenic miR-195 expression decreases the levels of SOX9 expression, along with reduced numbers of Paneth cells. Ectopically expressed SOX9 in the intestinal organoids derived from miR-195-Tg mice restores Paneth cell development ex vivo. miR-195 inhibits SOX9 translation by preventing binding of HuR to Sox9 mRNA. These findings suggest that interaction between miR-195 and HuR controls Paneth cell function via SOX9 in the intestinal epithelium.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00325.2024

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