LPS induces rapid increase in GDF15 levels in mice, rats, and humans but is not required for anorexia in mice-Reference-Cited by-同舟云学术

LPS induces rapid increase in GDF15 levels in mice, rats, and humans but is not required for anorexia in mice

Published:2022-02-01 Issue:2 Volume:322 Page:G247-G255
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Patel Anita R.¹²^ORCID,Frikke-Schmidt Henriette²,Bezy Olivier³,Sabatini Paul V.⁴,Rittig Nikolaj⁵⁶,Jessen Niels⁵^ORCID,Myers Martin G.⁴,Seeley Randy J.²⁴^ORCID

Affiliation:

1. Neuroscience Graduate Program, University of Michigan, Ann Arbor, Michigan

2. Department of Surgery, University of Michigan, Ann Arbor, Michigan

3. Was Internal Medicine Research Unit, Pfizer Inc., Cambridge, Massachusetts

4. Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan

5. Department of Diabetes and Hormone Diseases, Aarhus University Hospital, Aarhus, Denmark

6. Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark

Abstract

Although many responses to LPS depend on housing temperature, the anorexic response to LPS does not. LPS results in a potent and rapid increase in circulating levels of GDF15 in mice, rats, and humans. Nevertheless, GDF15 and its receptor (GFRAL) are not required for the anorexic response to systemic LPS administration. The anorexic response to LPS likely involves a myriad of complex physiological alterations.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Pfizer

American Diabetes Association

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00146.2021

Reference54 articles.

1. The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL