Unraveling the transcriptional determinants of liver sinusoidal endothelial cell specialization-Reference-Cited by-同舟云学术

Unraveling the transcriptional determinants of liver sinusoidal endothelial cell specialization

Published:2020-04-01 Issue:4 Volume:318 Page:G803-G815
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

de Haan Willeke¹,Øie Cristina²,Benkheil Mohammed³,Dheedene Wouter¹,Vinckier Stefan⁴⁵,Coppiello Giulia¹,Aranguren Xabier López¹,Beerens Manu¹,Jaekers Joris⁶,Topal Baki⁶,Verfaillie Catherine⁷,Smedsrød Bård²,Luttun Aernout¹^ORCID

Affiliation:

1. Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium

2. Vascular Biology Research Group, Department of Medical Biology, University of Tromsø – The Arctic University of Norway, Tromsø, Norway

3. Rega Institute, KU Leuven, Leuven, Belgium

4. Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Leuven, Belgium

5. Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, Vlaams Instituut voor Biotechnologie, Leuven, Belgium

6. Abdominal Surgery, Universitair Ziekenhuis Leuven, Leuven, Belgiuim

7. Stem Cell and Developmental Biology, Department of Development and Regeneration, KU Leuven, Leuven, Belgium

Abstract

Liver sinusoidal endothelial cells (LSECs) are the first liver cells to encounter waste macromolecules, pathogens, and toxins in the blood and are highly specialized. Although some transcription factors are known to play a role in LSEC specialization, information about the specialized LSEC signature and its transcriptional determinants remains incomplete. Here, we show that C-MAF, GATA4, and MEIS2 are important transcriptional regulators of the unique LSEC signature and that they affect the interaction of LSECs with viruses.

Funder

EC | European Research Council

Cosmetics Europe/ European commission FP7

KU Leuven Program Financing

Interuniversity attraction poles

Marie Sklodowska-Curie

FWO

IWT

KU Leuven C1 competitive funding

Publisher

American Physiological Society

Subject