Unraveling a novel transcription factor code determining the human arterial-specific endothelial cell signature

Author:

Aranguren Xabier L.1,Agirre Xabier2,Beerens Manu1,Coppiello Giulia1,Uriz Maialen2,Vandersmissen Ine1,Benkheil Mohammed1,Panadero Joaquin3,Aguado Natalia2,Pascual-Montano Alberto4,Segura Victor5,Prósper Felipe2,Luttun Aernout1

Affiliation:

1. Department of Cardiovascular Sciences, Molecular and Vascular Biology Research Unit, Endothelial Cell Biology Unit, KU Leuven, Leuven, Belgium;

2. Hematology and Cell Therapy Area, Clinica Universidad de Navarra, and Division of Oncology, Center for Applied Medical Research, University of Navarra, Pamplona, Spain;

3. Integromics, S.L., Parque Cientifico de Madrid, Madrid, Spain;

4. Functional Bioinformatics Group, National Center for Biotechnology (CNB-CSIC), Madrid, Spain; and

5. Department of Bioinformatics, CIMA, University of Navarra, Pamplona, Spain

Abstract

Key Points Freshly isolated arterial/venous endothelial cells differ in their gene signature, which is only partially controlled by the Notch pathway. Eight transcription factors codetermine the arterial fingerprint in a complementary and overlapping fashion.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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