Unraveling a novel transcription factor code determining the human arterial-specific endothelial cell signature-Reference-Cited by-同舟云学术

Unraveling a novel transcription factor code determining the human arterial-specific endothelial cell signature

Published:2013-12-05 Issue:24 Volume:122 Page:3982-3992
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Aranguren Xabier L.¹,Agirre Xabier²,Beerens Manu¹,Coppiello Giulia¹,Uriz Maialen²,Vandersmissen Ine¹,Benkheil Mohammed¹,Panadero Joaquin³,Aguado Natalia²,Pascual-Montano Alberto⁴,Segura Victor⁵,Prósper Felipe²,Luttun Aernout¹

Affiliation:

1. Department of Cardiovascular Sciences, Molecular and Vascular Biology Research Unit, Endothelial Cell Biology Unit, KU Leuven, Leuven, Belgium;

2. Hematology and Cell Therapy Area, Clinica Universidad de Navarra, and Division of Oncology, Center for Applied Medical Research, University of Navarra, Pamplona, Spain;

3. Integromics, S.L., Parque Cientifico de Madrid, Madrid, Spain;

4. Functional Bioinformatics Group, National Center for Biotechnology (CNB-CSIC), Madrid, Spain; and

5. Department of Bioinformatics, CIMA, University of Navarra, Pamplona, Spain

Abstract

Key Points Freshly isolated arterial/venous endothelial cells differ in their gene signature, which is only partially controlled by the Notch pathway. Eight transcription factors codetermine the arterial fingerprint in a complementary and overlapping fashion.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/24/3982/1370798/3982.pdf

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4. Endothelial cell diversity revealed by global expression profiling.;Chi;Proc Natl Acad Sci USA,2003

5. Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants.;Krebs;Genes Dev,2004

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