Helicobacter pyloriinfection impairs chaperone-assisted maturation of Na-K-ATPase in gastric epithelium

Author:

Marcus Elizabeth A.12,Tokhtaeva Elmira32,Jimenez Jossue L.12,Wen Yi32,Naini Bita V.4,Heard Ashley N.12,Kim Samuel2,Capri Joseph5,Cohn Whitaker5,Whitelegge Julian P.5,Vagin Olga32

Affiliation:

1. Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, California

2. Veterans Affairs Greater Los Angeles Health Care System, Los Angeles, California

3. Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, California

4. Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California

5. Pasarow Mass Spectrometry Laboratory, The Neuropsychiatric Insititute–Semel Institute, University of California, Los Angeles, California

Abstract

This work provides evidence that Helicobacter pylori decreases levels of Na-K-ATPase, a vital transport enzyme, in gastric epithelia, both in acutely infected cultured cells and in chronically infected patients and animals. The bacteria interfere with BiP-assisted folding of newly-made Na-K-ATPase subunits in the endoplasmic reticulum, accelerating their ubiquitylation and proteasomal degradation and decreasing efficiency of the assembly of native enzyme. Decreased Na-K-ATPase expression contributes to H. pylori-induced gastric injury.

Funder

NIH

UCLA Children's Discovery and Innovation Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

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