Feeding mode influences dynamic gut microbiota signatures and affects susceptibility to anti-CD3 mAb-induced intestinal injury in neonatal mice-Reference-Cited by-同舟云学术

Feeding mode influences dynamic gut microbiota signatures and affects susceptibility to anti-CD3 mAb-induced intestinal injury in neonatal mice

Published:2022-09-01 Issue:3 Volume:323 Page:G205-G218
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Subramanian Saravanan¹²,Geng Hua¹²,Du Chao¹²,Chou Pauline M.³,Bu Heng-Fu¹²,Wang Xiao¹²,Swaminathan Suchitra⁴,Tan Stephanie C.¹²,Ridlon Jason M.⁵,De Plaen Isabelle G.²⁶,Tan Xiao-Di¹²³⁷

Affiliation:

1. Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Center for Intestinal and Liver Inflammation Research, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, Illinois

2. Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois

3. Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois

4. Division of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois

5. Department of Animal Sciences, University of Illinois Urbana-Champaign, Urbana, Illinois

6. Division of Neonatology, Department of Pediatrics, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, Illinois

7. Department of Research and Development, Jesse Brown Department of Veterans Affairs Medical Center, Chicago, Illinois

Abstract

This report shows that a feeding mode profoundly affects gut colonization in neonatal mice. Furthermore, our results demonstrate that formula feeding predisposes mouse pups to anti-CD3 mAb-induced necrotizing enterocolitis (NEC)-like intestinal injury upon inadequate microbial colonization. The study suggests the role of the combined presence of formula feeding-associated dysbiosis and mucosal inflammation in the pathogenesis of NEC and provides a new mouse model to study this disease.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Institute of General Medical Sciences

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00337.2021

Reference79 articles.

1. Combination-Feeding Causes Differences in Aspects of Systemic and Mucosal Immune Cell Phenotypes and Functions Compared to Exclusive Sow-Rearing or Formula-Feeding in Piglets

2. Human milk microbiome: From actual knowledge to future perspective

3. Association between expressed breast milk feeding and breastfeeding duration in Hong Kong mothers

4. Formula diet alters small intestine morphology, microbial abundance and reduces VE-cadherin and IL-10 expression in neonatal porcine model

5. Formula feeding practice and associated factors among mothers with infants 0–6 months of age in Addis Ababa, Ethiopia: a community-based cross-sectional study

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. State-of-the-art review and update of in vivo models of necrotizing enterocolitis;Frontiers in Pediatrics;2023-04-04

2. Crosstalk between Gut Microbiota and Host Immunity: Impact on Inflammation and Immunotherapy;Biomedicines;2023-01-20