A novel mouse model of hepatocyte-specific apoptosis-induced myeloid cell-dominant sterile liver injury and repair response

Author:

Bu Heng-Fu12,Subramanian Saravanan12,Chou Pauline M.3ORCID,Liu Fangyi1,Sun Leyu3,Geng Hua12,Wang Xiao12,Liao Jie3,Du Chao4,Hu Joyce1,Tan Stephanie C.1,Nathan Nirmal1,Yang Guang-Yu3,Tan Xiao-Di12ORCID

Affiliation:

1. Department of Pediatrics, Pediatric Mucosal Inflammation and Regeneration Research Program, Center for Pediatric Translational Research and Education, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States

2. Department of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, United States

3. Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States

4. Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States

Abstract

Bu et al. present a triple-transgenic mouse model, namely, 3xTg-iHAP mice that are engineered to explore hepatocyte apoptosis-triggered sterile liver injury and regeneration. This model demonstrates a full spectrum of liver wound-healing responses from asymptomatic apoptosis to injury, myeloid cell-dominant sterile inflammation, and repair after induction of hepatocyte-specific apoptosis. The robust nature of this model makes it an invaluable in vivo tool for studying sterile liver inflammation, regeneration, and new therapeutic strategies.

Funder

HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

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