Cholestenoic acid as endogenous epigenetic regulator decreases hepatocyte lipid accumulation in vitro and in vivo-Reference-Cited by-同舟云学术

Cholestenoic acid as endogenous epigenetic regulator decreases hepatocyte lipid accumulation in vitro and in vivo

Published:2024-02-01 Issue:2 Volume:326 Page:G147-G162
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Wang Yaping¹²^ORCID,Pandak Williams M.¹²,Hylemon Phillip B.¹²,Min Hae-Ki¹²,Min John¹²,Fuchs Michael¹²,Sanyal Arun J.¹²,Ren Shunlin¹²

Affiliation:

1. Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia, United States;

2. McGuire Veterans Affairs Medical Center, Richmond, Virginia, United States

Abstract

To our knowledge, this study is the first to identify the mitochondrial monohydroxy bile acid cholestenoic acid (CA) as an endogenous epigenetic regulator that regulates lipid metabolism through epigenome modification in human hepatocytes. The methods used in this study are all big data analysis, and the results of each part show the global regulation of CA on human hepatocytes rather than narrow point effects.

Funder

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00184.2023

Reference53 articles.

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