Author:
Kondashevskaya M. V.,Artemyeva K. A.,Mikhaleva L. M.
Abstract
Abstract
Post-traumatic stress disorder (PTSD) is a maladaptive response
to the exposure of an extraordinary-intensity stressor. The animal
and human body responds to any external challenges at the systemic, organismal
and cellular levels. In stress-sensitive individuals, the collaboration
of stress-implementing and stress-limiting systems is compromised,
causing the transformation of behavior, cognitive abilities and
other functions of the central nervous system. It is commonly accepted
now that changes in the abundance and repertoire of the intestinal
microbiota play an important role in the pathogenesis of PTSD. In
this regard, the methods of improving the microflora are high on
the agenda. Analyzing the literature data, we came to the conclusion
that metabolic, somatic and mental health largely depends on the
coordinated functioning of the key interdependent metabolic components:
hepatobiliary system, intestinal microbiota and, as we believe,
the state of mast cells. Close scrutiny of the interplay of these components
will help identify new therapeutic targets and the most effective
methods to treat PTSD.