Evolutionary expansion of polyaspartate motif in the activation peptide of mouse cationic trypsinogen limits autoactivation and protects against pancreatitis-Reference-Cited by-同舟云学术

Evolutionary expansion of polyaspartate motif in the activation peptide of mouse cationic trypsinogen limits autoactivation and protects against pancreatitis

Published:2021-12-01 Issue:6 Volume:321 Page:G719-G734
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Orekhova Anna¹,Németh Balázs Csaba¹²,Jancsó Zsanett¹²,Geisz Andrea¹^ORCID,Mosztbacher Dóra¹,Demcsák Alexandra¹²,Sahin-Tóth Miklós¹²^ORCID

Affiliation:

1. Department of Molecular and Cell Biology, Center for Exocrine Disorders, Boston University, Henry M. Goldman School of Dental Medicine, Boston, Massachusetts

2. Department of Surgery, University of California Los Angeles, Los Angeles, California

Abstract

Unwanted autoactivation of the digestive protease trypsinogen can result in pancreatitis. The trypsinogen activation peptide contains a polyaspartate motif that suppresses autoactivation. This study demonstrates that evolutionary expansion of these aspartate residues in mouse cationic trypsinogen further inhibits autoactivation and enhances protection against pancreatitis.

Funder

AGA Research Foundation

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00265.2021

Reference26 articles.

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4. A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation

5. Mutation That Promotes Activation of Trypsinogen Increases Severity of Secretagogue-Induced Pancreatitis in Mice

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