Hyperuricemia is associated with impaired intestinal permeability in mice

Author:

Xu Daxing1,Lv Qiulan2,Wang Xiaofeng1,Cui Xuena2,Zhao Peng2,Yang Xiaomin2,Liu Xiu1,Yang Wan1,Yang Guanpin3,Wang Guangtao2,Wang Pengjun2,Wang Zenglan1,Li Zhiyuan2,Xing Shichao1245

Affiliation:

1. Department of Pathogenic Biology, School of Basic Medicine, Qingdao University, Qingdao, People’s Republic of China

2. Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China

3. The Key Laboratory of Mariculture of Chinese Ministry of Education, Ocean University of China, Qingdao, People’s Republic of China

4. Institute of Sports Medicine and Health, Qingdao University, Qingdao, People’s Republic of China

5. British Heart Foundation Centre of Research Excellence, School of Cardiovascular Medicine and Science, King’s College London, United Kingdom

Abstract

Hyperuricemia is associated with many metabolic diseases. However, the underlying mechanism remains unknown. The gut microbiota has been demonstrated to play significant roles in the immunity and metabolism of the host. In the present study, we constructed a hyperuricemic mouse model to investigate whether the metabolic disorder caused by hyperuricemia is related to intestinal dysbiosis. A significantly increased intestinal permeability was detected in hyperuricemic mice. The difference in microflora between wild-type and hyperuricemic mice accompanies the translocation of gut microbiota to the extraintestinal tissues. Such a process is followed by an increase in innate immune system activation. We observed increased LPS and TNF-α levels in the hyperuricemic mice, indicating that hyperuricemic mice were in a state of low-grade systemic inflammation. In addition, hyperuricemic mice presented early injury of parenteral tissue and disordered lipid metabolism. These findings suggest that intestinal dysbiosis due to an impaired intestinal barrier may be the key cause of metabolic disorders in hyperuricemic mice. Our findings should aid in paving a new way of preventing and treating hyperuricemia and its complications. NEW & NOTEWORTHY Hyperuricemia is associated with many metabolic diseases. However, the underlying mechanism remains unknown. We constructed a hyperuricemic mouse model to explore the relationship between intestinal dysbiosis and metabolic disorder caused by hyperuricemia.

Funder

National Natural Science Foundation of China

Distinguished Middle-Aged and Young Scientist Encourage and Reward Foundation of Shandong Province

Scientific and Technical Development Project of Department of health of Shandong Province

Natural Science Foundation of Shandong Province

Shandong Province Higher Educational Science and Technology Program

Scientific and Industrial Development Project of Qingdao

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

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