Affiliation:
1. Department of Physiology, University of Chicago, Chicago, Illinois
Abstract
The interaction of fasting, glucose availability and insulin on protein synthesis was investigated using the isolated rat diaphragm incubated in vitro with histidine-2-C14. Prior fasting of the diaphragm donor leads to a decrease in the rate of incorporation of histidine-2-C14 into muscle protein; the decrease after a 12- or 24-hour fast is small, that after a 48-hour fast is marked. A definite influence of glucose concentration can be demonstrated only when the donor rat has been fasted 48 hours; and only in diaphragms from such fasted animals is the insulin anabolic effect dependent on the availability of extracellular glucose.
Publisher
American Physiological Society
Cited by
97 articles.
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