Affiliation:
1. Department of Pharmacology, State University of New York, Upstate Medical Center, Syracuse, New York
Abstract
Rats starved for 48 hours and refed a high carbohydrate diet show an increase in hepatic lipogenesis and a marked increase in activity of the enzymes of entry into the HMP shunt. An analysis is given of the patterns of glucose-1-C14 and -6-C14 metabolism in liver slices of refed rats. At 24 and 48 hours the ratios of carbons 1 and 6 in both CO2 and lipid are consistent with an increase in glucose metabolism via the direct pathway, especially in view of the previous finding of elevated HMP dehydrogenase activity under these conditions. In addition, a description is given of the temporal relationships of glycogen deposition, lipogenesis recovery, and differentially labeled glucose metabolism in the first 12 hours of refeeding.
Publisher
American Physiological Society
Cited by
78 articles.
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