Sedentary time associates detrimentally and physical activity beneficially with metabolic flexibility in adults with metabolic syndrome-Reference-Cited by-同舟云学术

Sedentary time associates detrimentally and physical activity beneficially with metabolic flexibility in adults with metabolic syndrome

Published:2024-04-01 Issue:4 Volume:326 Page:E503-E514
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Garthwaite Taru¹^ORCID,Sjöros Tanja¹^ORCID,Laine Saara¹^ORCID,Koivumäki Mikko¹,Vähä-Ypyä Henri²^ORCID,Verho Tiina¹,Norha Jooa¹,Kallio Petri³⁴,Saarenhovi Maria³,Löyttyniemi Eliisa⁵,Sievänen Harri²^ORCID,Houttu Noora⁶,Laitinen Kirsi⁶^ORCID,Kalliokoski Kari K.¹^ORCID,Vasankari Tommi²⁷,Knuuti Juhani¹,Heinonen Ilkka¹^ORCID

Affiliation:

1. Turku PET Centre, University of Turku, Åbo Akademi University, and Turku University Hospital, Turku, Finland

2. The UKK Institute for Health Promotion Research, Tampere, Finland

3. Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland

4. Paavo Nurmi Centre and Unit for Health and Physical Activity, University of Turku, Turku, Finland

5. Department of Biostatistics, University of Turku and Turku University Hospital, Turku, Finland

6. Institute of Biomedicine, University of Turku, Turku, Finland

7. Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland

Abstract

High accelerometer-assessed sedentary time associates with metabolic inflexibility measured during hyperinsulinemic-euglycemic clamp in adults with metabolic syndrome, and more light-intensity and total physical activity associate with more metabolic flexibility. Physical activity behaviors may thus play an important role in the regulation of fuel metabolism. This highlights the potential of reduced sedentary time and increased physical activity of any intensity to induce metabolic health benefits and help in disease prevention in risk populations.

Funder

Diabetestutkimussäätiö

Juho Vainion Säätiö

Research Council of Finland

Suomen Kulttuurirahasto

Varsinais-Suomen Sairaanhoitopiiri

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00338.2023

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