Deletion of GABAB receptors from <i>Kiss1</i> cells affects glucose homeostasis without altering reproduction in male mice-Reference-Cited by-同舟云学术

Deletion of GABAB receptors from Kiss1 cells affects glucose homeostasis without altering reproduction in male mice

Published:2023-04-01 Issue:4 Volume:324 Page:E314-E329
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Di Giorgio Noelia P.¹^ORCID,Bizzozzero-Hiriart Marianne¹,Surkin Pablo N.¹,Repetto Esteban¹,Bonaventura María M.¹,Tabares Florencia N.¹,Bourguignon Nadia S.¹,Converti Ayelén¹^ORCID,Gomez Juan M. Riaño¹,Bettler Bernhard²,Lux-Lantos Victoria¹^ORCID

Affiliation:

1. Laboratorio de Neuroendocrinología, Instituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina

2. Department of Biomedicine, Pharmazentrum, University of Basel, Basel, Switzerland

Abstract

We developed a unique mouse lacking GABAB receptors specifically in Kiss1 cells to evaluate the impact on reproduction and metabolism. Knockout males showed a severe impact on glucose homeostasis, which worsened with aging. These results reinforce the proposed kisspeptin involvement in metabolic regulation and highlight the impact of GABA through GABABR in the regulation of the peripheral pancreas kisspeptin system.

Funder

Consejo Nacional de Investigaciones Científicas y Técnicas

International Society for Neurochemistry

MINCyT | Agencia Nacional de Promoción Científica y Tecnológica

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00129.2022

Reference85 articles.

1. Height and Weight at Menarche and a Hypothesis of Critical Body Weights and Adolescent Events

2. Metabolic regulation of kisspeptin — the link between energy balance and reproduction

3. Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54

4. TheGPR54Gene as a Regulator of Puberty

5. Chemical identity of hypothalamic neurons engaged by leptin in reproductive control