Metabolic regulation of kisspeptin — the link between energy balance and reproduction
Author:
Publisher
Springer Science and Business Media LLC
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism
Link
http://www.nature.com/articles/s41574-020-0363-7.pdf
Reference198 articles.
1. Manfredi-Lozano, M., Roa, J. & Tena-Sempere, M. Connecting metabolism and gonadal function: novel central neuropeptide pathways involved in the metabolic control of puberty and fertility. Front. Neuroendocrinol. 48, 37–49 (2018). This study is important in demonstrating the interaction between the melanocortin system and the reproductive axis, indicating that the reproductive action of melanocortins is kisspeptin-dependent.
2. Navarro, V. M. & Tena-Sempere, M. Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility. Nat. Rev. Endocrinol. 8, 40–53 (2011).
3. Goodman, R. L. et al. Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B. Endocrinology 148, 5752–5760 (2007).
4. Navarro, V. M. et al. Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse. J. Neurosci. 29, 11859–11866 (2009). The first study demonstrating the concept of kisspeptin ARC neurons as the GnRH pulse generator.
5. Clarkson, J. et al. Definition of the hypothalamic GnRH pulse generator in mice. Proc. Natl Acad. Sci. USA 114, E10216–E10223 (2017). This study demonstrates through a series of optogenetic approaches that kisspeptin ARC neurons are indeed the GnRH pulse generator.
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