Inhibition of the endocannabinoid system reverses obese phenotype in aged mice and partly restores skeletal muscle function-Reference-Cited by-同舟云学术

Inhibition of the endocannabinoid system reverses obese phenotype in aged mice and partly restores skeletal muscle function

Published:2023-02-01 Issue:2 Volume:324 Page:E176-E184
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Fajardo Lucas¹,Sanchez Phelipe¹,Salles Jérôme¹,Rigaudière Jean Paul¹,Patrac Véronique¹,Caspar-Bauguil Sylvie²³,Bergoglgio Camille²,Moro Cédric²^ORCID,Walrand Stéphane¹⁴,Le Bacquer Olivier¹^ORCID

Affiliation:

1. Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRAE), Université Clermont Auvergne, Clermont-Ferrand, France

2. Team MetaDiab, Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm/Paul Sabatier University UMR1297, Toulouse, France

3. Department of Clinical Biochemistry, Toulouse University Hospitals, Toulouse, France

4. Service de Nutrition Clinique, Hôpital Gabriel Montpied, Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Clermont-Ferrand, France

Abstract

In 24-month-old mice submitted to high-fat high-sucrose-induced obesity, inhibition of the endocannabinoid system by rimonabant reversed the obese phenotype by promoting adipose tissue browning and β-oxidation in the liver but not in skeletal muscle. These metabolism modifications are associated with improved skeletal muscle function.

Funder

Government of France

University of Clermont Auvergne

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00258.2022

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