Cannabidiol protects C2C12 myotubes against cisplatin-induced atrophy by regulating oxidative stress

Abstract

In an in vitro model, cisplatin treatment led to myotube atrophy associated with dysregulation of protein homeostasis and increased oxidative stress, resulting in increased apoptosis. Cotreatment with cannabidiol was able to prevent this phenotype by promoting protein homeostasis and reducing oxidative stress.