High-throughput LC-MS method to investigate postprandial lipemia: considerations for future precision nutrition research-Reference-Cited by-同舟云学术

High-throughput LC-MS method to investigate postprandial lipemia: considerations for future precision nutrition research

Published:2021-04-01 Issue:4 Volume:320 Page:E702-E715
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Mucinski Justine M.¹^ORCID,Vena Jennifer E.²,Ramos-Roman Maria A.³,Lassman Michael E.⁴,Szuszkiewicz-Garcia Magdalene⁵,McLaren David G.⁴,Previs Stephen F.⁴,Shankar Sudha S.⁴,Parks Elizabeth J.¹⁶^ORCID

Affiliation:

1. Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri

2. Alberta’s Tomorrow Project, CancerControl Alberta, Alberta Health Services, Calgary, Alberta, Canada

3. Division of Endocrinology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas

4. MRL, Merck & Co., Inc., Kenilworth, New Jersey

5. Methodist Mansfield Medical Center, Mansfield, Texas

6. Division of Gastroenterology and Hepatology, Department of Medicine, University of Missouri School of Medicine, Columbia, Missouri

Abstract

A novel method to test human intestinal lipid handling using stable isotope labeling is presented and, for the first time, plasma appearance and lipid turnover were quantified in 12 healthy men following meals with varying amounts of fat. The method can be applied to studies in precision nutrition characterizing individual response to support basic science research or drug development. This report discusses key questions for consideration in precision nutrition that were highlighted by the data.

Funder

Merck

University of Missouri

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00526.2020

Reference75 articles.

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