Exogenous succinate impacts mouse brown adipose tissue mitochondrial proteome and potentiates body mass reduction induced by liraglutide-Reference-Cited by-同舟云学术

Exogenous succinate impacts mouse brown adipose tissue mitochondrial proteome and potentiates body mass reduction induced by liraglutide

Published:2023-03-01 Issue:3 Volume:324 Page:E226-E240
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Gaspar Rodrigo S.¹²,Delafiori Jeany³,Zuccoli Giuliana⁴,Carregari Victor Corasolla⁴,Prado Thais P.¹,Morari Joseane¹,Sidarta-Oliveira Davi¹,Solon Carina S.¹,Catharino Rodrigo R.³,Araujo Eliana P.¹,Martins-de-Souza Daniel⁴⁵⁶⁷,Velloso Licio A.¹²^ORCID

Affiliation:

1. Laboratory of Cell Signaling-Obesity and Comorbidities Research Center, University of Campinas, Campinas, Brazil

2. National Institute of Science and Technology on Neuroimmunomodulation, Rio de Janeiro, Brazil

3. INNOVARE Biomarkers Laboratory, School of Pharmaceutical Sciences, University of Campinas, Campinas, Brazil

4. Laboratory of Neuroproteomics, Institute of Biology, University of Campinas, Campinas, Brazil

5. D’Or Institute for Research and Education, São Paulo, Brazil

6. Experimental Medicine Research Cluster (EMRC), University of Campinas, Campinas, Brazil

7. National Institute of Biomarkers in Neuropsychiatry, National Council for Scientific and Technological Development, São Paulo, Brazil

Abstract

Exogenous succinate induces major changes in brown adipose tissue protein expression affecting particularly mitochondrial respiration and structural proteins. When given exogenously in drinking water, succinate mitigates body mass gain in a rodent model of diet-induced obesity; in addition, when given in association with the glucagon-like peptide-1 receptor agonist, liraglutide, succinate increases body mass reduction promoted by liraglutide alone.

Funder

National Institute of Science and Technology on Neuroimmunomodulation, Brazil

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00231.2022

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1. Hypothalamic IRX3: A New Player in the Development of Obesity