Accelerated developmental adipogenesis programs adipose tissue dysfunction and cardiometabolic risk in offspring born to dams with metabolic dysfunction-Reference-Cited by-同舟云学术

Accelerated developmental adipogenesis programs adipose tissue dysfunction and cardiometabolic risk in offspring born to dams with metabolic dysfunction

Published:2021-11-01 Issue:5 Volume:321 Page:E581-E591
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Mikolajczak Anna¹²³,Sallam Nada A.¹²⁴,Singh Radha D.¹²⁵,Scheidl Taylor B.¹⁵³,Walsh Emma J.¹²,Larion Sebastian⁶,Huang Carol⁷²³,Thompson Jennifer A.¹²⁵³^ORCID

Affiliation:

1. Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada

2. Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

3. Alberta Children’s Hospital Research Institute, Calgary, Alberta, Canada

4. Faculty of Pharmacy, Cairo University, Giza, Egypt

5. Libin Cardiovascular Institute, Calgary, Alberta, Canada

6. Division of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, South Carolina

7. Department of Pediatrics, University of Calgary, Calgary, Alberta, Canada

Abstract

This study reveals that accelerated adipogenesis during the perinatal window of adipose tissue development predisposes to later life hypertrophic adipocyte dysfunction, thereby compromising the buffering function of the subcutaneous depot.

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development

Heart and Stroke Foundation of Canada

Canada Foundation for Innovation

Libin Cardiovascular Institute of Alberta

Alberta Children's Hospital Research Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

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