Inflammation and Oxidative Stress Induced by Obesity, Gestational Diabetes, and Preeclampsia in Pregnancy: Role of High-Density Lipoproteins as Vectors for Bioactive Compounds
-
Published:2023-10-23
Issue:10
Volume:12
Page:1894
-
ISSN:2076-3921
-
Container-title:Antioxidants
-
language:en
-
Short-container-title:Antioxidants
Author:
Jiménez-Osorio Angélica Saraí1ORCID, Carreón-Torres Elizabeth2ORCID, Correa-Solís Emmanuel3ORCID, Ángel-García Julieta1, Arias-Rico José1ORCID, Jiménez-Garza Octavio1, Morales-Castillejos Lizbeth1, Díaz-Zuleta Hugo Alexander4ORCID, Baltazar-Tellez Rosa María1, Sánchez-Padilla María Luisa1, Flores-Chávez Olga Rocío1, Estrada-Luna Diego1ORCID
Affiliation:
1. Área Académica de Enfermería, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado Hida go, Circuito Ex Hacienda La Concepción S/N, Carretera Pachuca-Actopan, San Agustín Tlaxiaca 42160, Hidalgo, Mexico 2. Department of Molecular Biology, Instituto Nacional de Cardiología “Ignacio Chávez”, Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, Mexico 3. Instituto de Farmacobiología, Universidad de la Cañada, Carretera Teotitlán-San Antonio Nanahuatipán Km 1.7 s/n., Paraje Titlacuatitla, Teotitlán de Flores Magón 68540, Oaxaca, Mexico 4. Facultad de Ciencias de la Salud, Universidad de Ciencias Aplicadas y Ambientales, Cl. 222 #54-21, Bogotá 111166, Colombia
Abstract
Inflammation and oxidative stress are essential components in a myriad of pathogenic entities that lead to metabolic and chronic diseases. Moreover, inflammation in its different phases is necessary for the initiation and maintenance of a healthy pregnancy. Therefore, an equilibrium between a necessary/pathologic level of inflammation and oxidative stress during pregnancy is needed to avoid disease development. High-density lipoproteins (HDL) are important for a healthy pregnancy and a good neonatal outcome. Their role in fetal development during challenging situations is vital for maintaining the equilibrium. However, in certain conditions, such as obesity, diabetes, and other cardiovascular diseases, it has been observed that HDL loses its protective properties, becoming dysfunctional. Bioactive compounds have been widely studied as mediators of inflammation and oxidative stress in different diseases, but their mechanisms of action are still unknown. Nonetheless, these agents, which are obtained from functional foods, increase the concentration of HDL, TRC, and antioxidant activity. Therefore, this review first summarizes several mechanisms of HDL participation in the equilibrium between inflammation and oxidative stress. Second, it gives an insight into how HDL may act as a vector for bioactive compounds. Third, it describes the relationships between the inflammation process in pregnancy and HDL activity. Consequently, different databases were used, including MEDLINE, PubMed, and Scopus, where scientific articles published in the English language up to 2023 were identified.
Funder
Universidad Autónoma del Estado de Hidalgo
Subject
Cell Biology,Clinical Biochemistry,Molecular Biology,Biochemistry,Physiology
Reference207 articles.
1. Anatomical and Physiological Alterations of Pregnancy;Kazma;J. Pharmacokinet. Pharmacodyn.,2020 2. Musculoskeletal Pain and Symptoms in Pregnancy: A Descriptive Study;Kesikburun;Ther. Adv. Musculoskelet. Dis.,2018 3. Cardiovascular Diseases in Pregnancy—A Brief Overview;Sahu;Curr. Cardiol. Rev.,2021 4. Pregnancy and Reproductive Risk Factors for Cardiovascular Disease in Women;Michos;Circ. Res.,2022 5. Estrada-Luna, D., Ortiz-Rodriguez, M.A., Medina-Briseño, L., Carreón-Torres, E., Izquierdo-Vega, J.A., Sharma, A., Cancino-Díaz, J.C., Pérez-Méndez, O., Belefant-Miller, H., and Betanzos-Cabrera, G. (2018). Current Therapies Focused on High-Density Lipoproteins Associated with Cardiovascular Disease. Molecules, 23.
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|