Sheep lactate entry-rate measurements: error due to sampling jugular blood.

Author:

Reilly P E,Chandrasena L G

Abstract

Carotid arterial and jugular venous blood samples were taken simultaneously during primed continuous infusions of L-[U-14C]lactate in four sheep. The mean rate (n = 4) of total net formation of lactate (0.394 +/- 0.047 mg C/min per kg) calculated from the results obtained by analyzing the jugular blood samples for lactate concentration and specific radioactivity was significantly higher (0.01 greater than P greater than 0.005) than the mean rate (n = 4) calculated from the results of analysis of the arterial samples (0.302 +/- 0.036 mg C/min per kg). The error in the estimation of the rate of total net formation of lactate due to jugular sampling resulted from the negative arteriovenous difference found for lactate across the tissues of the head. These results illustrate the general need for examination of the suitability of venous sampling in experiments that make use of the continuous infusion isotope-dilution method.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Cited by 17 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Bovine Acidosis: Implications on Laminitis;Journal of Dairy Science;1997-05

2. Lactate and pyruvate isotopic enrichments in plasma and tissues of postabsorptive and starved rats;American Journal of Physiology-Endocrinology and Metabolism;1995-05-01

3. V-A and A-V modes in whole body and regional kinetics: domain of validity from a physiological model;American Journal of Physiology-Endocrinology and Metabolism;1992-10-01

4. Effects of training on lactate production and removal during progressive exercise in humans;Journal of Applied Physiology;1992-05-01

5. Role of the circulation in measurement of lactate turnover rate;Journal of Applied Physiology;1991-04-01

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