T-cell factor 7L2 is a novel regulator of osteoblast functions that acts in part by modulation of hypoxia signaling-Reference-Cited by-同舟云学术

T-cell factor 7L2 is a novel regulator of osteoblast functions that acts in part by modulation of hypoxia signaling

Published:2022-06-01 Issue:6 Volume:322 Page:E528-E539
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Mohan Subburaman¹²³,Kesavan Chandrasekhar¹²^ORCID

Affiliation:

1. Musculoskeletal Disease Center, VA Loma Linda Healthcare System, Loma Linda, California

2. Department of Medicine, School of Medicine, Loma Linda University, Loma Linda, California

3. Department of Orthopedics, School of Medicine, Loma Linda University, Loma Linda, California

Abstract

TCF7L2 is expressed by bone but it was not known whether TCF7L2 expression influenced bone development. By using a mouse model with conditional disruption of Tcf7l2 in osteoblast lineage cells, we have demonstrated for the first time, to our knowledge, that TCF7L2 plays an important role in regulating osteoblasts via a noncanonical pathway.

Funder

HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00035.2022

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