Conditional Deletion of Insulin-Like Growth Factor-I in Collagen Type 1α2-Expressing Cells Results in Postnatal Lethality and a Dramatic Reduction in Bone Accretion

Author:

Govoni Kristen E.1,Wergedal Jon E.12,Florin Lore3,Angel Peter3,Baylink David J.2,Mohan Subburaman12

Affiliation:

1. Musculoskeletal Disease Center (K.E.G., J.E.W., S.M.), Jerry L. Pettis Veterans Affairs Medical Center, Loma Linda, California 92357;

2. Department of Medicine (J.E.W., D.J.B., S.M.), Loma Linda University, Loma Linda, California 92354;

3. German Cancer Research Center (L.F., P.A.), D-69120 Heidelberg, Germany

Publisher

The Endocrine Society

Subject

Endocrinology

Reference44 articles.

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2. Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions.;Rajaram;Endocr Rev,1997

3. Impaired skeletal growth in mice with haploinsufficiency of IGF-I: genetic evidence that differences in IGF-I expression could contribute to peak bone mineral density differences.;Mohan;J Endocrinol,2005

4. Insulin-like growth factor regulates peak bone mineral density in mice by both growth hormone-dependent and -independent mechanisms.;Mohan;Endocrinology,2003

5. Insulin-like growth factors and their binding proteins: biological actions.;Jones;Endocr Rev,1995

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