Altered glucose kinetics occurs with aging: a new outlook on metabolic flexibility-Reference-Cited by-同舟云学术

Altered glucose kinetics occurs with aging: a new outlook on metabolic flexibility

Published:2024-08-01 Issue:2 Volume:327 Page:E217-E228
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Curl Casey C.¹,Leija Robert G.¹^ORCID,Arevalo Jose A.¹^ORCID,Osmond Adam D.¹,Duong Justin J.¹,Huie Melvin J.¹,Masharani Umesh²,Horning Michael A.¹,Brooks George A.¹^ORCID

Affiliation:

1. Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States

2. Department of Endocrinology, School of Medicine, University of California, San Francisco, California, United States

Abstract

To determine metabolic flexibility in response to an OGTT, we studied healthy young and older men and women to determine glucose kinetics and changes in RER. Compared to young subjects, glucose kinetics were suppressed in older healthy individuals during an OGTT. Surprisingly, the age-related changes in glucose flux were not reflected in RER measurements; thus, RER measurements do not give a complete view of metabolic flexibility in healthy individuals.

Funder

HHS | NIH | National Institute on Aging

University of California Berkeley

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00091.2024

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