Bioavailability of starch and postprandial changes in splanchnic glucose metabolism in pigs

Abstract

Changes in splanchnic metabolism in pigs were assessed after meals containing slowly or rapidly digested starch. The pigs were fed a mixed meal containing a “slow” native ( n = 5) or a “rapid” pregelatinized ( n = 5) cornstarch naturally enriched with [13C]glucose. Absorption of [13C]glucose was monitored by the arteriovenous difference technique, and infusion ofd-[6,6-2H2]glucose in the jugular vein was used to calculate the systemic appearance of [13C]glucose. Arteriovenous balance data obtained during a 12-h study period showed that the fraction of ingested glucose equivalent appearing as glucose in the portal vein was 49.7 ± 7.2% for the slow starch and 48.2 ± 7.5% for the rapid starch ( P = 0.86). These values, corrected for the gut extraction of circulating [13C]glucose, became 66.4 ± 5.6 and 65.3 ± 5.6%, respectively ( P = 0.35). Isotope dilution data indicated that systemic appearance of exogenous [13C]glucose represented 62.9 ± 7.6 and 67.4 ± 3.0% of the oral load for slow and rapid starch, respectively ( P = 0.68). Arterial glucose utilization by the gut increased from 7.3 ± 0.9 μmol ⋅ kg− 1 ⋅ min− 1before the meal to 8.5 ± 1.6 μmol ⋅ kg− 1 ⋅ min− 1during absorption, independently of the nature of the starch. Thus splanchnic glucose metabolism was unaffected by the nature of starch ingested.