Thrombospondin-1, CD47, and SIRPα display cell-specific molecular signatures in human islets and pancreata-Reference-Cited by-同舟云学术

Thrombospondin-1, CD47, and SIRPα display cell-specific molecular signatures in human islets and pancreata

Published:2023-04-01 Issue:4 Volume:324 Page:E347-E357
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Erdem Neslihan¹²³⁴^ORCID,Chen Kuan-Tsen³⁴,Qi Meirigeng³⁴,Zhao Yuqi⁵,Wu Xiwei⁵,Garcia Isaac²⁴,Ku Hsun Teresa¹³⁴,Montero Enrique⁴,Al-Abdullah Ismail H.³⁴,Kandeel Fouad³⁴,Roep Bart O.⁴,Isenberg Jeffrey S.⁶⁴^ORCID

Affiliation:

1. Irell & Manella Graduate School of Biological Sciences, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States

2. Department of Molecular & Cellular Endocrinology, City of Hope National Medical Center, Duarte, California, United States

3. Department of Translational Research & Cellular Therapeutics, City of Hope National Medical Center, Duarte, California, United States

4. Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope National Medical Center, Duarte, California, United States

5. Integrative Genomics Core, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States

6. Department of Diabetes Complications & Metabolism, City of Hope National Medical Center, Duarte, California, United States

Abstract

CD47 is a cell surface receptor with two primary ligands, soluble thrombospondin-1 (TSP1) and cell surface signal regulatory protein alpha (SIRPα). Both interactions provide checkpoints for immune cell activity. We determined that fresh human islets display CD47 and secrete TSP1. However, human islet endocrine cells lack SIRPα. These gene signatures are likely important given the increasing use of CD47 and SIRPα blocking molecules in individuals with cancer.

Funder

City Of Hope National Medical Center

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00221.2022

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