Exerkine apelin reverses obesity-associated placental dysfunction by accelerating mitochondrial biogenesis in mice-Reference-Cited by-同舟云学术

Exerkine apelin reverses obesity-associated placental dysfunction by accelerating mitochondrial biogenesis in mice

Published:2022-06-01 Issue:6 Volume:322 Page:E467-E479
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Chae Song Ah¹^ORCID,Son Jun Seok²,Zhao Liang¹,Gao Yao¹,Liu Xiangdong¹,Marie de Avila Jeanene¹,Zhu Mei-Jun³,Du Min¹^ORCID

Affiliation:

1. Nutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State University, Pullman, Washington

2. Laboratory of Perinatal Kinesioepigenetics, Department of Obstetrics, Gynecology & Reproductive Sciences, University of Maryland School of Medicine, Baltimore, Maryland

3. School of Food Science, Washington State University, Pullman, Washington

Abstract

Maternal exercise prevents metabolic disorders of mothers and offspring induced by high-fat diet. Exercise intervention enhances PRDM16 activation, oxidative metabolism, and vascularization of placenta, which are inhibited due to maternal obesity. Similar to maternal exercise, apelin administration improves placental function of obese dams.

Funder

HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00023.2022

Reference70 articles.

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