1. Division of Advanced Diagnostics, Toronto General Research Institutes, University Health Network, Toronto, Ontario, Canada;
2. Division of Endocrinology and Metabolism, the Keenan Research Centre in the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada;
3. Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada;
4. Department of Physiology, University of Toronto, Toronto, Ontario, Canada; and
5. College of Life Science, Graduate University of Chinese Academy of Sciences, Beijing, China