Insulin infusion decreases medium-sized extracellular vesicles in adults with metabolic syndrome-Reference-Cited by-同舟云学术

Insulin infusion decreases medium-sized extracellular vesicles in adults with metabolic syndrome

Published:2022-10-01 Issue:4 Volume:323 Page:E378-E388
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Heiston Emily M.¹²,Ballantyne Anna²,Stewart Nathan R.²³,La Salvia Sabrina⁴^ORCID,Musante Luca⁴^ORCID,Lanningan Joanne⁵,Erdbrügger Uta⁴,Malin Steven K.²³⁶⁷⁸^ORCID

Affiliation:

1. Department of Internal Medicine, Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia

2. Department of Kinesiology, University of Virginia, Charlottesville, Virginia

3. Department of Kinesiology & Health, Rutgers University, New Brunswick, New Jersey

4. Division of Nephrology, Department of Medicine, University of Virginia, Charlottesville, Virginia

5. Flow Cytometry Support Services, LLC, Alexandria, Virginia

6. Division of Endocrinology, Metabolism & Nutrition, Department of Medicine, Rutgers University, New Brunswick, New Jersey

7. The New Jersey Institute for Food, Nutrition and Health, Rutgers University, New Brunswick, New Jersey

8. Institute of Translational Medicine and Science, Rutgers University, New Brunswick, New Jersey

Abstract

This study is one of the first to investigate the effects of insulin on medium and larger extracellular vesicles (EVs) in relation to metabolic insulin sensitivity and fuel use in adults with metabolic syndrome. Our data suggest that insulin infusion decreases the concentration of total particle counts, mainly due to reductions in medium-sized EVs. Furthermore, EVs, predominantly medium-sized, are inversely associated with metabolic flexibility.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

University of Virginia

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00022.2022

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