Primate Antisaccade. II. Supplementary Eye Field Neuronal Activity Predicts Correct Performance

Author:

Amador Nelly1,Schlag-Rey Madeleine1,Schlag John1

Affiliation:

1. Department of Neurobiology and Brain Research Institute, University of California School of Medicine, Los Angeles, California 90095-1763

Abstract

Neuronal activities were recorded in the supplementary eye field (SEF) of 3 macaque monkeys trained to perform antisaccades pseudorandomly interleaved with prosaccades, as instructed by the shape of a central fixation point. The prosaccade goal was indicated by a peripheral stimulus flashed anywhere on the screen, whereas the antisaccade goal was an unmarked site diametrically opposite the flashed stimulus. The visual cue was given immediately after the instruction cue disappeared in the immediate-saccade task, or during the instruction period in the delayed-saccade task. The instruction cue offset was the saccade gosignal. Here we focus on 92 task-related neurons: visual, eye-movement, and instruction/fixation neurons. We found that 73% of SEF eye-movement–related neurons fired significantly more before anti-saccades than prosaccades. This finding was analyzed at 3 levels: population, single neuron, and individual trial. On individual antisaccade trials, 40 ms before saccade, the firing rate of eye-movement–related neurons was highly predictive of successful performance. A similar analysis of visual responses (40 ms astride the peak) gave less-coherent results. Fixation neurons, activated during the initial instruction period (i.e., after the instruction cue but before the stimulus) always fired more on antisaccade than on prosaccade trials. This trend, however, was statistically significant for only half of these neurons. We conclude that the SEF is critically involved in the production of antisaccades.

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Reference98 articles.

1. Amador N, Schlag-Rey M, and Schlag J. Supplementary eye field (SEF) activity in monkeys can predict the successful performance of antisaccade tasks. Soc Neurosci Abstr 22: 419, 1996.

2. Amador N, Schlag-Rey M, and Schlag J. Differential activity in the monkey supplementary eye field (SEF) during fixation of the instruction cue for antisaccades and prosaccades. Soc Neurosci Abstr 23: 474, 1997.

3. Primate Antisaccades. I. Behavioral Characteristics

4. Reward-Predicting and Reward-Detecting Neuronal Activity in the Primate Supplementary Eye Field

5. Amador N, Schlag-Rey M, and Schlag J. SEF neuronal activity before antisaccades predicts correct performance. Soc Neurosci Abstr 27: 59.9, 2001.

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