Ampakine pretreatment enables a single hypoxic episode to produce phrenic motor facilitation with no added benefit of additional episodes-Reference-Cited by-同舟云学术

Ampakine pretreatment enables a single hypoxic episode to produce phrenic motor facilitation with no added benefit of additional episodes

Published:2021-10-01 Issue:4 Volume:126 Page:1420-1429
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Thakre Prajwal P.¹²³,Sunshine Michael D.¹²³^ORCID,Fuller David D.¹²³

Affiliation:

1. Department of Physical Therapy, University of Florida, Gainesville, Florida

2. Breathing Research and Therapeutics Center, University of Florida, Gainesville, Florida

3. McKnight Brain Institute, University of Florida, Gainesville, Florida

Abstract

Pretreatment with ampakine CX717 created conditions that enabled an acute bout of moderate hypoxia to evoke phrenic motor facilitation, but this response was not observed when ampakine pretreatment was followed by intermittent hypoxia. Thus, in anesthetized and spinal intact rats, the combination of ampakine and one bout of hypoxia appears ideal for triggering respiratory neuroplasticity.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00307.2021

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