Effects of Ih and TASK-like shunting current on dendritic impedance in layer 5 pyramidal-tract neurons

Author:

Kelley Craig1ORCID,Dura-Bernal Salvador23,Neymotin Samuel A.34,Antic Srdjan D.5ORCID,Carnevale Nicholas T.6,Migliore Michele7,Lytton William W.128910

Affiliation:

1. Program in Biomedical Engineering, SUNY Downstate Health Sciences University and NYU Tandon School of Engineering, Brooklyn, New York

2. Department of Physiology and Pharmacology, SUNY Downstate Health Sciences University, Brooklyn, New York

3. Center for Biomedical Imaging and Neuromodulation, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York

4. Department of Psychiatry, NYU Grossman School of Medicine, New York City, New York

5. Neuroscience Department, Institute of Systems Genomics, University of Connecticut Health, Farmington, Connecticut

6. Department of Neuroscience, Yale University, New Haven, Connecticut

7. Institute of Biophysics, National Research Council, Palermo, Italy

8. Department of Neurology, SUNY Downstate Health Sciences University, Brooklyn, New York

9. Department of Neurology, Kings County Hospital Center, Brooklyn, New York

10. The Robert F. Furchgott Center for Neural and Behavioral Science, Brooklyn, New York

Abstract

We simulated chirp current stimulation in the apical dendrites of 5 biophysically detailed multicompartment models of neocortical pyramidal tract neurons and found that a combination of HCN channels and TASK-like channels produced the best fit to experimental measurements of dendritic impedance. We then explored how HCN and TASK-like channels can shape the dendritic impedance as well as the voltage response to synaptic currents.

Funder

DOD | United States Army | RDECOM | Army Research Office

HHS | NIH | National Institute on Deafness and Other Communication Disorders

HHS | National Institutes of Health

National Science Foundation

New York State Department of Health

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

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