An epidural stimulating interface unveils the intrinsic modulation of electrically motor evoked potentials in behaving rats-Reference-Cited by-同舟云学术

An epidural stimulating interface unveils the intrinsic modulation of electrically motor evoked potentials in behaving rats

Published:2021-11-01 Issue:5 Volume:126 Page:1635-1641
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Taccola Giuliano¹²^ORCID,Culaclii Stanislav³⁴^ORCID,Zhong Hui¹,Gad Parag⁵,Liu Wentai³⁶⁷,Edgerton V. Reggie⁵⁶⁸⁹

Affiliation:

1. Department of Integrative Biology and Physiology, University of California, Los Angeles, California

2. Neuroscience Department, International School for Advanced Studies (SISSA), Trieste, Italy

3. Department of Bioengineering, University of California, Los Angeles, California

4. NASA Jet Propulsion Laboratory, California Institute of Technology, Pasadena, California

5. Department of Neurobiology, University of California, Los Angeles, California

6. Brain Research Institute, University of California, Los Angeles, California

7. UCLA California NanoSystems Institute, Los Angeles, California

8. Department of Neurosurgery, University of California, Los Angeles, California

9. Institut Guttmann, Hospital de Neurorehabilitació, Institut Universitari adscrit a la Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain

Abstract

Chronic implants of a new epidural stimulating interface trace dynamics of spinal excitability in awake rats, before and after injury. Motor evoked potentials induced by trains of pulses at sub-motor threshold intensity were continuously modulated in amplitude. Oscillatory patterns of amplitude modulation reduced with increasing strengths of stimulation and were replaced by an intrinsic stochastic tone under anesthesia. Variability of baseline excitability is a fundamental feature of spinal networks, affecting their responses to external input.

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00278.2021

Reference16 articles.

1. Epidural electric stimulation of posterior structures of the human lumbar spinal cord: 1. muscle twitches – a functional method to define the site of stimulation

2. Plasticity of Spinal Cord Reflexes After a Complete Transection in Adult Rats: Relationship to Stepping Ability

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4. Engaging Spinal Networks to Mitigate Supraspinal Dysfunction After CP

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